Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
Document Type
Article
Publication Date
2017
Digital Object Identifier (DOI)
https://doi.org/10.1021/acsmedchemlett.7b00045
Abstract
From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
ACS Medicinal Chemistry Letters, v. 8, issue 8, p. 802-807
Scholar Commons Citation
Giulianotti, Marc A.; Vesely, Brian A.; Azhari, Ala; Souza, Ashley; LaVoi, Travis; Houghten, Richard A.; Kyle, Dennis E.; and Leahy, James W., "Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries" (2017). Chemistry Faculty Publications. 182.
https://digitalcommons.usf.edu/chm_facpub/182
