Identification of Novel Inhibitors that Disrupt STAT3–DNA Interaction from a γ-AApeptide OBOC Combinatorial Library

Authors

Peng Teng, University of South Florida
Xiaolei Zhang, University of South Florida
Haifan Wu, University of South Florida
Qiao Qiao, University of South Florida
Said M. Sebti, University of South Florida
Jianfeng Cai, University of South FloridaFollow

Document Type

Article

Publication Date

2014

Digital Object Identifier (DOI)

https://doi.org/10.1039/C4CC03909B

Abstract

From a γ-AApeptide-based one-bead-one-compound (OBOC) combinatorial library, we identified γ-AApeptides that can selectively inhibit STAT3–DNA interaction and suppress the expression levels of STAT3 target genes in intact cells. Our results demonstrate that in addition to the SH2 domain, the DNA binding domain of STAT3 is targetable for the development of a new generation of anti-cancer therapeutics.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Chemical Communication, v. 50, p. 8739-8742

Scholar Commons Citation

Teng, Peng; Zhang, Xiaolei; Wu, Haifan; Qiao, Qiao; Sebti, Said M.; and Cai, Jianfeng, "Identification of Novel Inhibitors that Disrupt STAT3–DNA Interaction from a γ-AApeptide OBOC Combinatorial Library" (2014). Chemistry Faculty Publications. 158.
https://digitalcommons.usf.edu/chm_facpub/158