Document Type
Article
Publication Date
2018
Keywords
DNA methylation, DNA hydroxymethylation, MDS, AML, CLL, TETs, DNMTs
Digital Object Identifier (DOI)
http://.doi.org/10.21926/obm.genet.1804054
Abstract
Epigenetic dysregulation is present in both myeloid and lymphoid disorders, with important differences reported between myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), on one hand, and chronic lymphocytic leukemia (CLL), on the other. Qualitative differences are reported in MDS/AML with gene fusions (e.g. TET1/LCX) and somatic mutations in epigenetic regulators (e.g. DNMT3A, TET2, IDH1/2), while differences in CLL are predominantly quantitative (e.g. DNMT3A, TET2). Indeed, and as supported by studies in animal models, a defective DNA methylation/demethylation process represents a competitive advantage to the myeloid lineage and an early event in MDS/AML, while in the case of CLL, epigenetic events appear later and are associated with disease progression. Finally, in both MDS/AML and CLL, the focal or global DNA methylation/demethylation process is altered and contributes to disease progression and activity. In conclusion, a better understanding of the epigenetic regulators involved in myeloid/lymphoid differentiation, their localization and the co-recruitment of other proteins at specific DNA target sites, could offer us the possibility to modulate hematopoiesis, and control disease initiation and/or progression.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
OBM Genetics, v. 2, issue 4, art. 054
Scholar Commons Citation
Bagacean, Cristina; Bordron, Anne; Adrian, Tempescul; Ianotto, Jean Christophe; Guillerm, Gaelle; Brooks, Wesley; Couturier, Marie-Anne; Zdrenghea, Mihnea; Berthou, Christian; and Renaudineau, Yves, "Distinct Mechanisms of Alterations in DNA Methylation/Demethylation Leading to Myelodysplastic Syndromes/Acute Myeloid Leukemia and Chronic Lymphocytic Leukemia" (2018). Chemistry Faculty Publications. 134.
https://digitalcommons.usf.edu/chm_facpub/134
