Document Type
Patent
Publication Date
11-7-2017
Patent Number
9808513
CPC
A61K 38/2242 (20130101)
Abstract
A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 .mu.M), 84% (1 mM), 31% (1 .mu.M), and 30% (1 .mu.M), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 .mu.M concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.
Application Number
14/310,258
Recommended Citation
Vesely, David L., "Method of treatment of cancer using guanosine 3', 5' cyclic monophosphate (cyclic GMP)" (2017). USF Patents. 934.
https://digitalcommons.usf.edu/usf_patents/934
Assignees
University of South Florida
Filing Date
2014-06-20
