Document Type
Patent
Publication Date
11-7-2017
Patent Number
9808448
CPC
A61K 31/4439 (20130101)
Abstract
Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.
Application Number
15/484,445
Recommended Citation
Gestwicki, Jason E. and Dickey, Chad, "Pharmaceutical compounds and use of same in cancer and tauopathies" (2017). USF Patents. 933.
https://digitalcommons.usf.edu/usf_patents/933
Assignees
University of South Florida
Filing Date
2017-04-11
