Document Type
Patent
Publication Date
March 2014
Patent Number
8668905
Abstract
The present invention relates to immunotherapy methods for treating hyperproliferative disease in humans, particularly to hyperproliferative disease that is refractory to therapy. More specifically, the invention is directed, in one embodiment, to methods for treating a subject with a hyperproliferative disease in which the expression of a self gene is upregulated in therapy-resistant hyperproliferative cells. In another embodiment, an adenoviral expression construct comprising a self gene under the control of a promoter operable in eukaryotic cells is administered to the therapy-resistant hyperproliferative cells. The present invention thus provides immunotherapies for treating therapy-resistant hyperproliferative disease by attenuating the natural immune system's CTL response against hyperproliferative cells or overexpressing mutant p53 antigens, for example.
Application Number
11/433,079
Recommended Citation
Antonia, Scott; Gabrilovich, Dmitry I.; Chada, Sunil; and Menander, Kerstin B., "P53 vaccines for the treatment of cancers" (2014). USF Patents. 92.
https://digitalcommons.usf.edu/usf_patents/92
Assignees
University of South Florida
Filing Date
05/12/2006
Primary/U.S. Class
424/932
