Document Type
Patent
Publication Date
February 2014
Patent Number
8655598
Abstract
This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an algorithm, a systems model was generated of the radiosensitivity network. The network consists of ten highly interconnected genetic hubs with significant signal redundancy. The model was validated with in vitro tests perturbing network components, correctly predicting radiation sensitivity ⅔ times. The model's clinical relevance was shown by linking clinical radiosensitivity targets to the model network. Clinical applications were confirmed by testing model predictions against clinical response to preoperative radiochemotherapy in patients with rectal or esophageal cancer.
Application Number
13/037,156
Recommended Citation
Torres-Roca, Javier F. and Eschrich, Steven, "Predictive radiosensitivity network model" (2014). USF Patents. 88.
https://digitalcommons.usf.edu/usf_patents/88
Assignees
University of South Florida H. Lee Moffitt Cancer Center and Research Institute, Inc.
Filing Date
02/28/2011
Primary/U.S. Class
702/19
