Vasoactive effects and free radical generation by .beta.-amyloid peptides

Authors

Thomas N. Thomas
Michael Mullan
Gary W. Arendash
Fiona C. Crawford
Zhiming Suo

Document Type

Patent

Publication Date

January 2000

Patent Number

60110198

Abstract

A method is disclosed for treating and preventing diseases, wherein at least one of the causes of the disease is .beta.-amyloid peptide induced change in free radical production resulting in vascular endothelial dysfunction and vasoactivity, by antagonizing vascular free radicals in excess of functional equilibrium. An animal model for the disease is also disclosed.

Application Number

08/747,457

Recommended Citation

Thomas, Thomas N.; Mullan, Michael; Arendash, Gary W.; Crawford, Fiona C.; and Suo, Zhiming, "Vasoactive effects and free radical generation by .beta.-amyloid peptides" (2000). USF Patents. 825.
https://digitalcommons.usf.edu/usf_patents/825

Assignees

University of South Florida

Filing Date

11/12/1996

Primary/U.S. Class

514/43