Document Type
Patent
Publication Date
November 2001
Patent Number
6314316a
Abstract
The manipulator includes a support and at least one member affixed to and extending away from the support. The member has at least two differentially activatable electrodes. The electrodes are configured to establish a first electromagnetic field in vivo between selected electrodes sufficient to manipulate a molecule relative to a target tissue and to establish a second, typically higher, electromagnetic field sufficient to cause transient permeability of a cell membrane within the target tissue. One method of using the device is for enhancing the delivery of a molecule into a tissue site. In a related embodiment the device may be used to cause the electromigration of at least two components of a multicomponent reactive system into apposition to permit a reaction to occur at a desired target tissue site. The target tissue may comprise a tumor, organ, or wound site.
Application Number
09/213,218
Recommended Citation
Gilbert, Richard; Jaroszeski, Mark; and Heller, Richard, "Nonpenetrating electroporation device and method" (2001). USF Patents. 808.
https://digitalcommons.usf.edu/usf_patents/808
Assignees
University of South Florida
Filing Date
12/17/1998
Primary/U.S. Class
604/20
