Method and composition for treatment of ischemic neuronal reperfusion injury

Authors

Harpal S. Mangat
Gerry Ballough
Gary Brown

Document Type

Patent

Publication Date

October 2002

Patent Number

6462066

Abstract

Methods and compositions for treatment of, or protection from, neuropathy resulting from reperfusion injury upon reversal of an ischemic condition, comprising treatment or prophylactic treatment of the patient with an antagonist of the type 3 ryanodine receptor, such that a rise in cytosolic Ca²⁺ concentration is prevented. Therapeutic compositions containing dantrolene or aminodantrolene are administered to the patient to prevent a rise in cytosolic Ca²⁺ that would otherwise result in Ca²⁺ -mediated neuronal damage. Treatment of ischemic optic neuropathy by this method is shown, and the methods and compositions presented are also applicable to other ischemic reperfusion neuropathies, such as stroke, reperfusion injury after TPA treatment/carotid endarterectomy, seizures, and excitotoxic retinal damage in glaucoma.

Application Number

09/727,707

Recommended Citation

Mangat, Harpal S.; Ballough, Gerry; and Brown, Gary, "Method and composition for treatment of ischemic neuronal reperfusion injury" (2002). USF Patents. 793.
https://digitalcommons.usf.edu/usf_patents/793

Assignees

University of South Florida

Filing Date

12/04/2000

Primary/U.S. Class

514/398