Compounds and methods for modulating cell-adhesion mediated drug resistance

Authors

William S. Dalton
Jason S. Damiano
Anne E. Cress

Document Type

Patent

Publication Date

11-2-2004

Patent Number

6812003

Abstract

Peptides and methods of their use for inhibiting drug and radiation-therapy resistance in cancerous cells in which efficacy of chemotherapy and/or radiotherapy of a patient is enhanced by administration of an effective amount of a peptide that inhibits cell adhesion mediated drug resistance (CAM-DR). Preferably, the peptide comprises D-amino acids having the sequence: kmviywkag (RZ-3) or is a variant or modified version thereof. The peptide is preferably administered to the patient prior to chemotherapy and/or radiation therapy. Inhibition of cell adhesion mediated drug resistance (CAM-DR) by RZ-3 in multiple myeloma cells is disclosed.

Application Number

10/024,017

Recommended Citation

Dalton, William S.; Damiano, Jason S.; and Cress, Anne E., "Compounds and methods for modulating cell-adhesion mediated drug resistance" (2004). USF Patents. 768.
https://digitalcommons.usf.edu/usf_patents/768

Assignees

University of South Florida

Filing Date

12/21/2001

Primary/U.S. Class

435/691