Document Type

Patent

Publication Date

February 2005

Patent Number

6852529

Abstract

The subject invention pertains to nucleic acid constructs for post-transcriptional control of expression of a ploynucleotide encoding a protein in a eukaryotic cell, wherein the constructs include a metabolite responsive instability element such as the glucose-regulated mRNA instability element. The subject invention further pertains to host cells and vectors comprising the nucleic acid constructs of the invention, as well as probes, methods, and kits for detecting metabolite responsive instability elements or mutations thereof.

Application Number

09/435,471

Assignees

University of South Florida

Filing Date

11/08/1999

Primary/U.S. Class

435/325

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