Document Type
Patent
Publication Date
August 2007
Patent Number
7253149
Abstract
Peptides and methods of their use for inhibiting drug and radiation-therapy resistance in cancerous cells in which efficacy of chemotherapy and/or radiotherapy of a patient is enhanced by administration of an effective amount of a peptide that inhibits cell adhesion mediated drug resistance (CAM-DR). Preferably, the peptide comprises D-amino acids having the sequence: kmviywkag (RZ-3) or is a variant or modified version thereof. The peptide is preferably administered to the patient prior to chemotherapy and/or radiation therapy. Inhibition of cell adhesion mediated drug resistance (CAM-DR) by RZ-3 in multiple myeloma cells is disclosed.
Application Number
10/978,202
Recommended Citation
Dalton, William S.; Damiano, Jason S.; and Cress, Anne E., "Compounds and methods for modulating cell-adhesion mediated drug resistance" (2007). USF Patents. 631.
https://digitalcommons.usf.edu/usf_patents/631
Assignees
University of South Florida
Filing Date
10/29/2004
Primary/U.S. Class
514/15
