Document Type
Patent
Publication Date
December 2009
Patent Number
7638122
Abstract
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activating T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.
Application Number
10/383,707
Recommended Citation
Yu, Hua; Pardoll, Drew; and Jove, Richard, "Stat3 antagonists and their use as vaccines against cancer" (2009). USF Patents. 584.
https://digitalcommons.usf.edu/usf_patents/584
Assignees
University of South Florida
Filing Date
03/07/2003
Primary/U.S. Class
424/937
