Document Type
Patent
Publication Date
September 2015
Patent Number
9121806
CPC
G01N 27/02(20130101), A61B 5/145(20130101), G01N 33/4836(20130101), G01N 33/54366(20130101), G01N 33/54373(20130101)
Abstract
An electrical impedance sensing device which integrates multielectrode automated impedance spectroscopy capability with automatic parameter extraction and data analysis to create an automated cell behavior monitoring system. The device comprises radial electrodes and an out-of-plane counter electrode. Quantitative impedance data provided information on cell adhesion, spreading, proliferation and detachment due to cell cycle processes as well as cell-drug interaction, with spatio-temporal resolution. The resulting dataset is processed for impedance distribution and used to characterize cellular motion, morphology, electrochemical and dielectric properties. Also, a method is described for studying cell-cell and cell-matrix interactions, determining electrical characteristics of cell layers, and identifying specific impedance parameters for cancer screening, drug screening, bacterial growth monitoring, organ transplant compatibility, and cell-drug interaction among other applications.
Application Number
12/180,982
Recommended Citation
Bhansali, Shekhar and Rahman, Abdur Rub Abdur, "Impedance spectroscopy-based cellular analysis device" (2015). USF Patents. 51.
https://digitalcommons.usf.edu/usf_patents/51
Assignees
University of South Florida
Filing Date
07/28/2008
