Document Type
Patent
Publication Date
April 2010
Patent Number
7691821
Abstract
The instant invention teaches the inhibition of SHIP expression, or function, for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such a leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo expansion and mobilization of other organ-specific stem cell populations (e.g., mesenchymal, mammary).
Application Number
10/709,801
Recommended Citation
Desponts, Caroline; Wahle, Joseph; Ninos, John; and Kerr, William G., "Inhibition of SHIP to enhance stem cell harvest and transplantation" (2010). USF Patents. 476.
https://digitalcommons.usf.edu/usf_patents/476
Assignees
University of South Florida
Filing Date
05/28/2004
Primary/U.S. Class
514/44
