Document Type
Patent
Publication Date
November 2011
Patent Number
8057826
Abstract
The present invention provides isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), which simultaneously express a plurality of genes that are markers for multiple cell lineages, wherein the multiple cell lineages comprise at least four different mesenchymal cell lineages (e.g., adipocyte, osteoblast, fibroblast, and muscle cell) and wherein each of the markers is specific for a single cell lineage. The present invention also method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures for characterization of and uses, particularly therapeutic uses for such cells. Specifically, isolated MPCs can be used for diagnostic purposes, to enhance the engraftment of hematopoietic progenitor cells, enhance bone marrow transplantation, or aid in the treatment or prevention of graft versus host disease.
Application Number
12/123,377
Recommended Citation
Seshi, Beerelli, "Methods for reducing graft-versus-host disease using pluri-differentiated mesenchymal progenitor cells" (2011). USF Patents. 441.
https://digitalcommons.usf.edu/usf_patents/441
Assignees
University of South Florida
Filing Date
05/19/2008
Primary/U.S. Class
424/577
