Document Type
Patent
Publication Date
August 2011
Patent Number
8008539
Abstract
The present invention relates to a novel animal model for neurological degenerative diseases, especially autism, relating to overexpression of human secreted APP-alpha. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals. Moreover, a method for the evaluation of the in vivo effects of a test compound on secreted APP-alpha expression and autism pathology in these animals is provided.
Application Number
12/727,679
Recommended Citation
Tan, Jun; Nikolic, William; and Hou, Huyan, "Generation of transgenic human soluble amyloid precursor protein alpha expressing mice" (2011). USF Patents. 427.
https://digitalcommons.usf.edu/usf_patents/427
Assignees
University of South Florida
Filing Date
03/19/2010
Primary/U.S. Class
800/18
