Document Type
Patent
Publication Date
June 2011
Patent Number
7960434
Abstract
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents.
Application Number
11/805,217
Recommended Citation
Turkson, James; Sebti, Said M.; Guida, Wayne; Yip, Man Lun; Lawrence, Nicholas J.; Lawrence, Harshani; and Greedy, Benjamin, "Small molecule inhibitors of STAT3 with anti-tumor activity" (2011). USF Patents. 407.
https://digitalcommons.usf.edu/usf_patents/407
Assignees
University of South Florida
Filing Date
05/21/2007
Primary/U.S. Class
514/518