Document Type
Patent
Publication Date
March 2012
Patent Number
8133692
Abstract
Methods are provided for predicting responsiveness of cancer cells to chemotherapy by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Also provided are methods of selecting a chemotherapeutic treatment for a subject diagnosed with cancer by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Kits for performing the methods are also provided. Methods for modulating Survivin-dependent apoptosis in a cancer cell are also disclosed.
Application Number
11/490,316
Recommended Citation
Jove, Richard; Minton, Susan E.; Muro-Cacho, Carlos A.; Sullivan, Daniel; Haura, Eric Bruce; and Bepler, Gerold, "Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments" (2012). USF Patents. 301.
https://digitalcommons.usf.edu/usf_patents/301
Assignees
University of South Florida
Filing Date
07/20/2006
Primary/U.S. Class
435/792
