Document Type
Patent
Publication Date
June 2015
Patent Number
9044431
CPC
A61K 35/14(20130101), A61K 35/30(20130101), A61K 38/185(20130101), A61K 38/1866(20130101)
Abstract
A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good source of stem cells for cell therapy. Menstrual blood is found to be another important source of stem cells. Assays of cultured menstrual blood reveal that they express embryonic like-stem cell phenotypic markers and neuronal phenotypic markers under appropriate conditioned media. Oxygen glucose deprivation stroke models show that OGD-exposed primary rat neurons, co-cultured with menstrual blood-derived stem cells or exposed to the media from cultured menstrual blood, exhibited significantly reduced cell death. Transplantation of menstrual blood-derived stem cells, either intracerebrally or intravenously, after experimentally induced ischemic stroke in adult rats also significantly reduced behavioral and histological impairments compared to vehicle-infused rats.
Application Number
13/107,391
Recommended Citation
Sanberg, Paul R.; Borlongan, Cesario V.; and Allickson, Julie, "Methods of treating stroke using stem cell-like menstrual blood cells" (2015). USF Patents. 28.
https://digitalcommons.usf.edu/usf_patents/28
Assignees
University of South Florida
Filing Date
05/13/2011
