Document Type
Patent
Publication Date
December 2013
Patent Number
8603458
Abstract
The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells genetically modified with a nucleotide sequence encoding IL-12 and IFN-γ.
Application Number
12/476,896
Recommended Citation
Mohapatra, Shyam S. and Kumar, Mukesh, "Genetic adjuvants for immunotherapy" (2013). USF Patents. 278.
https://digitalcommons.usf.edu/usf_patents/278
Assignees
University of South Florida
Filing Date
06/02/2009
Primary/U.S. Class
424/932
