Document Type
Patent
Publication Date
September 2013
Patent Number
8536324
CPC
C08B 37/003(20130101), Y10S 977/742(20130101), Y10S 977/75(20130101), Y10S 977/753(20130101)
Abstract
Functionalized Single Wall Carbon Nanotube (SWCNT) complexed with nanochitosan for use in the delivery of bioaffecting substances and diagnostic applications. fSWCNT complexed with the chitosan NG042 were used for delivery of DNA-encoding EGFP reporter protein and peptide. The results demonstrate that shown CNT-chitosan hybrid nanoparticles exhibit significantly higher transfection efficiency in vivo than chitosan alone. Furthermore, the functionalized nanotubes were tested for peptide transfer into HEK293 cells. The results showed that the hybrid nanoparticles efficiently transferred peptides. Together, these results show that hybrid SWCNT-chitosan particles increase DNA and peptide transfer into cells.
Application Number
12/105,884
Recommended Citation
Mohapatra, Shyam S. and Kumar, Arun, "Method of drug delivery by carbon nanotube-chitosan nanocomplexes" (2013). USF Patents. 240.
https://digitalcommons.usf.edu/usf_patents/240
Assignees
University of South Florida
Filing Date
04/18/2008
Primary/U.S. Class
536/551
