Document Type

Patent

Publication Date

September 2013

Patent Number

8524947

Abstract

The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.

Application Number

12/867,812

Assignees

University of South Florida H. Lee Moffitt Cancer Center and Research Institute, Inc.

Filing Date

02/23/2009

Primary/U.S. Class

564/85

Share

COinS