Document Type
Patent
Publication Date
February 2013
Patent Number
8383347
Abstract
Changes in adaptive immune system were identified and correlated as a predictor of Aβ40 and Aβ42 and AD progression. T-cell, B-cell, TCR and BCR profiles were used to correlate clinical progression of AD. The CDR3 region was spectratyped, showing the clonality of the CDR3 region. This intrafamily gene fragment length profile was compared to age-matched controls, thereby indicating the existence of a neurodegenerative disease. The novel method is useful in diagnosing neurodegenerative disease, like Parkinson's disease, HIV-associated Dementia, or Alzheimer's disease. Moreover, this permits the clinical identification of patients at a very early stage of AD and/or monitoring the potential benefits of disease modifying therapeutics.
Application Number
12/772,728
Recommended Citation
Cao, Chuanhai; Lin, Xiaoyang; and Potter, Huntington, "Method of diagnosing or assessing risk for Parkinson's disease or Alzheimer's disease using TCR clonality" (2013). USF Patents. 199.
https://digitalcommons.usf.edu/usf_patents/199
Assignees
University of South Florida
Filing Date
05/03/2010
Primary/U.S. Class
435/612
