Document Type
Patent
Publication Date
November 2014
Patent Number
8877752
CPC
C07D 215/233(20130101), C07D 413/04(20130101), C07D 401/04(20130101), C07D 215/56(20130101)
Abstract
Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.
Application Number
13/661,300
Recommended Citation
Manetsch, Roman; Cross, Richard Matthew; Namelikonda, Niranjan Kumar; Kyle, Dennis Edward; Mutka, Tina Susanna; LaCrue, Alexis Nichole; Maignan, Jordany Richarlson; and Saenz, Fabian Ernesto, "4(1H)-quinolones having antimalarial activity with reduced chemical resistance" (2014). USF Patents. 168.
https://digitalcommons.usf.edu/usf_patents/168
Assignees
University of South Florida
Filing Date
10/26/2012
Primary/U.S. Class
514/235
