Document Type
Patent
Publication Date
September 2014
Patent Number
8846653
Abstract
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PACA2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed.
Application Number
13/653,108
Recommended Citation
Malafa, Mokenge P. and Sebti, Said M., "Delta-tocotrienol treatment and prevention of pancreatic cancer" (2014). USF Patents. 158.
https://digitalcommons.usf.edu/usf_patents/158
Assignees
University of South Florida
Filing Date
10/16/2012
Primary/U.S. Class
514/183
