Document Type
Patent
Publication Date
August 2014
Patent Number
8802647
Abstract
The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleotide encoding 2-5 AS, or at least one catalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient in need thereof. The present inventors have determined that overexpression of 2-5AS causes a reduction in epithelial cell damage, reduction in infiltration of mononuclear cells in the peribronchiolar and perivascular regions, and reduction in thickening of the septa in the lungs. Levels of chemokines, such as MIP1-α, are also reduced upon overexpression of 2-5AS. The subject invention also pertains to pharmaceutical compositions containing a nucleotide sequence encoding 2-5 AS and a pharmaceutically acceptable carrier, as well as vectors for delivery of the 2-5 AS nucleotide sequence.
Application Number
13/621,470
Recommended Citation
Mohapatra, Shyam S. and Behera, Aruna K., "Materials and methods for prevention and treatment of RNA viral diseases" (2014). USF Patents. 148.
https://digitalcommons.usf.edu/usf_patents/148
Assignees
University of South Florida
Filing Date
09/17/2012
Primary/U.S. Class
514/44
