HSP90 activator AHA1 drives production of pathological tau aggregates

Authors

Chad Dickey
Lindsey Shelton
Brian Blagg
John Koren
Laura Jenelle Blair

Document Type

Article

Publication Date

March 2024

Patent Number

11931373

CPC

A61K 31/366 , A61K 31/7048 , A61P 25/28

Abstract

Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.

Application Number

17/722011

Recommended Citation

Dickey, Chad; Shelton, Lindsey; Blagg, Brian; Koren, John; and Blair, Laura Jenelle, "HSP90 activator AHA1 drives production of pathological tau aggregates" (2024). USF Patents. 1410.
https://digitalcommons.usf.edu/usf_patents/1410

Assignees

University of South Florida

Filing Date

04/15/2022