Document Type
Article
Publication Date
February 2024
Patent Number
11896644
Abstract
As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein.
Application Number
17/798041
Recommended Citation
Woo, Jung A.; Liggett, Stephen Bryant; Kang, David E.; Chen, Yu; and Lewandowski, Eric, "Inhibition of beta-arrestin oligomerization in tauopathy" (2024). USF Patents. 1406.
https://digitalcommons.usf.edu/usf_patents/1406
Assignees
UNIVERSITY OF SOUTH FLORIDA
Filing Date
02/08/2021
