Document Type
Article
Publication Date
January 2024
Patent Number
11857679
CPC
A61K 9/1075 , A61K 31/496 , A61K 47/20 , A61K 47/552 , A61K 47/58 , A61K 47/6907 , A61P 31/04 , Y02A 50/30
Abstract
The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coli. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.
Application Number
17/472819
Recommended Citation
Turos, Edward and Mahzamani, Faeez, "Nanoparticles carrying antibiotics" (2024). USF Patents. 1398.
https://digitalcommons.usf.edu/usf_patents/1398
Assignees
UNIVERSITY OF SOUTH FLORIDA
Filing Date
09/13/2021
