Document Type

Article

Publication Date

November 2023

Patent Number

11806328

CPC

A61P 17/02

Abstract

Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.

Application Number

17/122479

Assignees

UNIVERSITY OF SOUTH FLORIDA

Filing Date

12/15/2020

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