Document Type
Patent
Publication Date
July 2014
Patent Number
8778894
Abstract
The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.
Application Number
14/046,381
Recommended Citation
Tan, Jun; Luo, Deyan; and Shytle, Roland Douglas, "Luteolin and diosmin/diosmetin as novel STAT3 inhibitors for treating autism" (2014). USF Patents. 137.
https://digitalcommons.usf.edu/usf_patents/137
Assignees
University of South Florida
Filing Date
10/04/2013
Primary/U.S. Class
514/27
