Document Type
Article
Publication Date
October 2023
Patent Number
11793177
CPC
A01K 67/0276
Abstract
The present invention concerns non-human animals with cells having a genome that is lacking the entire E3 ubiquitin ligase (Ube3a) gene (including all isoforms and alternative promoters). These animals are useful for modeling Angelman Syndrome. The invention also includes methods for assessing the effect of an agent, such as potential therapeutics, on an animal model by exposing the animal or cells, tissues, or organs isolated therefrom, to an agent of interest.
Application Number
16/330871
Recommended Citation
Weeber, Edwin John; Segal, David J.; O'Geen, Henriette; Pyles, Benjamin; and Dindot, Scott V., "Animal model of Angelman Syndrome" (2023). USF Patents. 1368.
https://digitalcommons.usf.edu/usf_patents/1368
Assignees
UNIVERSITY OF SOUTH FLORIDA
Filing Date
10/03/2017
