Document Type
Article
Publication Date
September 2023
Patent Number
11752220
CPC
C12N 15/113
Abstract
A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.
Application Number
17/395683
Recommended Citation
Mohapatra, Shyam S.; Mohapatra, Subhra; and Markoutsa, Eleni, "Method of delivering genes and drugs to a posterior segment of an eye" (2023). USF Patents. 1351.
https://digitalcommons.usf.edu/usf_patents/1351
Assignees
The United States Government as Represented by the Department of Veterans Affair
Filing Date
08/06/2021
