Document Type
Patent
Publication Date
June 2014
Patent Number
8759317
CPC
A61K 31/708(20130101), A61K 38/22(20130101), C07K 14/58(20130101), Y10S 930/05(20130101)
Abstract
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.
Application Number
11/162,056
Recommended Citation
Vesely, David L., "Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)" (2014). USF Patents. 131.
https://digitalcommons.usf.edu/usf_patents/131
Assignees
University of South Florida
Filing Date
08/26/2005
Primary/U.S. Class
514/48
