Document Type
Article
Publication Date
November 2021
Patent Number
11185528
CPC
A61K 31/357, A61P 11/00
Abstract
Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.
Application Number
16/839517
Recommended Citation
Kolliputi, Narasaiah; Lockey, Richard F.; and Galam, Lakshmi, "ALDA-1 treatment and prevention of pulmonary disease" (2021). USF Patents. 1279.
https://digitalcommons.usf.edu/usf_patents/1279
Assignees
University of South Florida
Filing Date
04/03/2020
