Document Type

Article

Publication Date

November 2021

Patent Number

11185528

CPC

A61K 31/357, A61P 11/00

Abstract

Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.

Application Number

16/839517

Assignees

University of South Florida

Filing Date

04/03/2020

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