A61N 1/327, A61N 5/0625, A61N 2005/0652, A61F 7/007, A61F 2007/0071
A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature. The method may be used to deliver a molecule such as a vaccine or therapeutic to a biological structure, such as for prevention or treatment of SARS-CoV-2 infection.
Heller, Richard; Heller, Loree C.; and Jaroszeski, Mark Jeffery, "Targeted delivery of molecules using impedance-based monitoring at elevated temperatures" (2021). USF Patents. 1263.
University of South Florida