Document Type
Article
Publication Date
September 2021
Patent Number
11123554
CPC
A61N 1/327, A61N 5/0625, A61N 2005/0652, A61F 7/007, A61F 2007/0071
Abstract
A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature. The method may be used to deliver a molecule such as a vaccine or therapeutic to a biological structure, such as for prevention or treatment of SARS-CoV-2 infection.
Application Number
17/104833
Recommended Citation
Heller, Richard; Heller, Loree C.; and Jaroszeski, Mark Jeffery, "Targeted delivery of molecules using impedance-based monitoring at elevated temperatures" (2021). USF Patents. 1263.
https://digitalcommons.usf.edu/usf_patents/1263
Assignees
University of South Florida
Filing Date
11/25/2020
