Document Type
Article
Publication Date
April 2021
Patent Number
10974045
CPC
A61N 1/327, A61N 5/0625, A61N 2005/0652, A61N 1/325, A61F 7/007, A61F 2007/0071
Abstract
A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.
Application Number
16/999417
Recommended Citation
Jaroszeski, Mark Jeffery and Heller, Richard, "Targeted delivery of molecules using impedence-based monitoring at elevated temperatures" (2021). USF Patents. 1243.
https://digitalcommons.usf.edu/usf_patents/1243
Assignees
University of South Florida
Filing Date
08/21/2020
