Document Type
Article
Publication Date
April 2021
Patent Number
10973776
CPC
A61K 31/56, A61K 31/58, A61K 9/7015
Abstract
The present invention provides a sustained drug delivery system for the treatment of age-related macular degeneration (AMD), comprising corticosteroid encapsulated nanoparticles incorporated into a thermoreversible hydrogel. The corticosteroid may be triamcinolone acetate (TA), dexamethasone, or loteprednol etabonate (LE). The proposed drug delivery system is nontoxic to ARPE-19 (retinal pigment epithelium) cells and significantly reduces VEGF (vascular endothelial growth factor) expression as compared to solutions of the coticosteroids. The present invention provides sustained delivery of the corticosteroid to the posterior segment of the eye, reducing the frequency of intraocular injections necessary to maintain therapeutic concentrations.
Application Number
16/892423
Recommended Citation
Sutariya, Vijaykumar Bhadabhai; Hirani, Anjali A.; and Pathak, Yashwant V., "Loteprednol etabonate nanoparticles in thermoreversible gels for enhanced therapeutics" (2021). USF Patents. 1241.
https://digitalcommons.usf.edu/usf_patents/1241
Assignees
University of South Florida
Filing Date
06/04/2020
