Document Type
Article
Publication Date
March 2021
Patent Number
10947512
Abstract
Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain embodiments provide RSV having a mutated NS1 protein, where the mutation causes the uncoupling of the NS1 protein's replication and type I interferon (IFN) antagonist functions. In some embodiments, this uncoupling can produce virions capable of inducing a strong, long-lasting innate immune response while maintaining its ability to replicate in vitro. Also provided are methods for amplifying RSV in host cells, wherein amplified RSV has mutated NS1 protein in which the protein's replication and IFN antagonistic functions are uncoupled. In certain embodiments, the amplified RSV having mutated NS1 protein is formulated into immunogenic compositions, including vaccines. Other embodiments provide methods for inducing an effective immune response against RSV infection in a subject.
Application Number
15/752548
Recommended Citation
Peeples, Mark Edward; Teng, Michael Nan-hao; Ramilo, Octavio; Mejias, Maria Asuncion; and Flano, Emilio, "Respiratory syncytial virus having altered NS1 protein function and related materials and methods" (2021). USF Patents. 1237.
https://digitalcommons.usf.edu/usf_patents/1237
Assignees
Research Institute at Nationwide Children's Hospital
Filing Date
08/12/2016
