Document Type

Article

Publication Date

December 2020

Patent Number

10864184

CPC

A61P 17/02, A61K 9/0019, A61K 9/005, A61K 9/006, A61K 31/047

Abstract

Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.

Application Number

14/554172

Assignees

University of South Florida

Filing Date

11/26/2014

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