Document Type
Article
Publication Date
October 2020
Patent Number
10814015
Abstract
The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding human FKBP51 operably linked to a tetracycline response element. In some embodiments, the transgenic animal comprises an additional transgenic nucleotide sequence, integrated into the genome of the animal, comprising a nucleotide sequence encoding a tetracycline transactivator (tTA) operably linked to a promoter; wherein the tTA is expressed upon activation of the promoter and binds the tetracycline response element, thereby causing expression of FKBP51. The invention also pertains to methods for screening for agents for the prevention and/or treatment of psychiatric disorders, such as depression.
Application Number
15/602985
Recommended Citation
Dickey, Chad; Zhang, Bo; and Blair, Laura Jenelle, "Transgenic mouse model for conditional FKBP51 expression and related methods" (2020). USF Patents. 1206.
https://digitalcommons.usf.edu/usf_patents/1206
Assignees
University of South Florida
Filing Date
05/23/2017
