Document Type
Article
Publication Date
September 2020
Patent Number
10765755
CPC
A61K 47/48915, A61K 9/5123, A61K 31/5415
Abstract
A delivery system of coated and uncoated nanoparticles (NP) for delivery of methylene blue (MB). The delivery system was developed using PLGA-based polymer that was repeatedly shown to be biocompatible and biodegradable. The parameters of synthesized NPs were within the suitable range for BBB permeationâspecifically, the NPs were monodispersed, with slight negative charge, and with the size within 100-150 nm range suitable for intravenous delivery and delivery to the brain. The coating on the nanoparticle did not have a significant impact on the nanoparticle size and zeta potential. Based on the immunoblotting experiments using AD cellular model, the GSH coated NPs were better in reducing tau levels compared to MB solution. In vitro BBB Transwell permeation study showed eight fold higher MB-NP permeation compared to the MB solution over 24 hours.
Application Number
14/548996
Recommended Citation
Jinwal, Umesh Kumar and Sutariya, Vijaykumar Bhadabhai, "Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies" (2020). USF Patents. 1198.
https://digitalcommons.usf.edu/usf_patents/1198
Assignees
University of South Florida
Filing Date
11/20/2014
