Document Type
Article
Publication Date
August 2020
Patent Number
10729744
Abstract
Disclosed are methods of influencing, and enhancing, cognitive function and memory by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
Application Number
15/943058
Recommended Citation
Weeber, Edwin; Zhao, Lisa; and Peters, Melinda, "Reelin rescues cognitive function" (2020). USF Patents. 1188.
https://digitalcommons.usf.edu/usf_patents/1188
Assignees
University of South Florida
Filing Date
04/02/2018