Document Type
Article
Publication Date
May 2020
Patent Number
10646462
Abstract
Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol/L), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance in a short period of time. Further, use of these supplements to achieve ketosis yields a significant elevation of blood ketones and reduction of blood glucose levels. Use of these substances does not adversely affect lipid profiles. By initiating rapid ketosis and accelerating the rate of ketoadaptation, this invention is useful for the avoidance of glucose withdrawal symptoms commonly experienced by individuals initiating a ketogenic diet, and minimizes the loss of lean body mass during dietary restriction.
Application Number
15/610668
Recommended Citation
D'Agostino, Dominic Paul; Arnold, Patrick; and Kesl, Shannon, "Compositions and methods for producing elevated and sustained ketosis" (2020). USF Patents. 1162.
https://digitalcommons.usf.edu/usf_patents/1162
Assignees
University of South Florida
Filing Date
06/01/2017
