Toll-like receptor 2 ligands and methods of making and using thereof

Authors

David L. Morse
Josef Vagner
Mark McLaughlin
Robert Gillies
Amanda Huynh
Michael Doligalski

Document Type

Article

Publication Date

November 2018

Patent Number

10118942

CPC

A61K 49/00, A61K 2123/00, A61K 2121/00, A61K 49/0032, A61K 49/0052, A61K 51/00, A61K 51/0497, A61K 49/0019, C07K 5/081

Abstract

Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

Application Number

15/561230

Recommended Citation

Morse, David L.; Vagner, Josef; McLaughlin, Mark; Gillies, Robert; Huynh, Amanda; and Doligalski, Michael, "Toll-like receptor 2 ligands and methods of making and using thereof" (2018). USF Patents. 1084.
https://digitalcommons.usf.edu/usf_patents/1084

Assignees

H. Lee Moffitt Cancer Center and Research Institute, Inc.

Filing Date

03/25/2016