Document Type
Patent
Publication Date
April 2014
Patent Number
8691799
Abstract
The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the invention concerns methods of inhibiting the growth of a tumor by administering a cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK and/or STAT3 inhibition and anti-tumor activity.
Application Number
13/209,937
Recommended Citation
Sebti, Said M. and Jove, Richard, "Materials and methods for treatment of cancer and identification of anti-cancer compounds" (2014). USF Patents. 101.
https://digitalcommons.usf.edu/usf_patents/101
Assignees
University of South Florida
Filing Date
08/15/2011
Primary/U.S. Class
514/177
