Neurological Connections and Endogenous Biochemistry - Potentially Useful in Electronic-Nose Diagnostics for Coronavirus Diseases

Authors

• Tiffany C. Miller, University of South Florida
• Salvatore D. Morgera, University of South FloridaFollow
• Stephen E. Saddow, University of South FloridaFollow
• Arash Takshi, University of South FloridaFollow
• Matthew T. Mullarkey, University of South FloridaFollow
• Matthew Palm, Valhall K-9 International

Document Type

Article

Publication Date

2021

Keywords

COVID-19, biomarkers, neuroinflammation, volatile organic compounds, CNS disease, inflammatory response

Digital Object Identifier (DOI)

https://doi.org/10.20517/2347-8659.2021.05

Abstract

As our understanding of infectious diseases, such as coronavirus diseases including, Coronavirus Disease 2019 (COVID-19), as well as human respiratory viral and nonviral diseases, improves, we expect to uncover a better understanding of the pathogenesis of the disease as it relates to neuroinflammation. This may include associated biomarkers of immune response for neuroinflammation, central nervous system injury, and/or peripheral nervous system injury emitted from the breath and/or odor of an individual. Electronic nose gas sensing technology may have the potential to substantially slow the spread of contagious diseases with rapid diagnostic signal indication for detecting these emitted biomarkers of disease. The biochemistry behind the disease is critical for revealing the target gasses emitted in the breath of a severe acute respiratory syndrome coronavirus (SARS-CoV-2) infected individual for the development of such a selective diagnostic screening tool. In this paper, we comprehensively review the evidence that SARS-CoV-2 infection involves an inflammatory response mechanism involving the olfactory nerve route in the brain from the nasal canal suggesting potential candidate volatile organic compound target gas biomarkers, forming the breath pattern signature of COVID-19, that may be detected by electronic nose technologies from a breath sample.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Neuroimmunology and Neuroinflammation, v. 8, p. 285-296

Scholar Commons Citation

Miller, Tiffany C.; Morgera, Salvatore D.; Saddow, Stephen E.; Takshi, Arash; Mullarkey, Matthew T.; and Palm, Matthew, "Neurological Connections and Endogenous Biochemistry - Potentially Useful in Electronic-Nose Diagnostics for Coronavirus Diseases" (2021). School of Information Systems and Management Faculty Publications. 56.
https://digitalcommons.usf.edu/qmb_facpub/56